ea0077oc4.1 | Adrenal and Cardiovascular | SFEBES2021
Sander Kerstin
, Gendron Thibault
, Cybulska Klaudia A.
, Sirindil Faith
, Zhou Jonhua
, Kalber Tammy L.
, Lythgoe Mark F.
, Kurzawinski Tom R.
, Brown Morris J.
, Arstad Erik
Background: Inappropriately high aldosterone in patients with primary hyperaldosteronism (PHA) is due to increased aldosterone synthase (CYP11B2) activity. Selective in vivo imaging of overexpressed CYP11B2 in adrenals with positron emission tomography (PET) has not yet been achieved due to close homology of enzymes involved in aldosterone and cortisol (CYP11B1) synthesis.Aim: Synthesize a fluorine-18 labelled highly selective CYP11B2 inhibitor,...